NFKB1 and osteoarthritis: In the context of osteoarthritis, NF-κB is known to be involved in the downregulation of proteoglycan and collagen type II synthesis [22,23] and stimulation of matrix-degrading enzyme expression, including aggrecanases (ADAMTS4, ADAMTS5) and matrix metalloproteinases [24], like MMP13 [23,25].