CD274 and lung adenoma: Manling et al. reported that ginsenoside RK1 significantly inhibited the proliferation and induced apoptosis by regulating the NF-κB pathway through controlling PD-L1 expression in lung adenoma cells [19], and Fan et al. suggested that niclosamide enhances the efficacy of PD-1/PD-L1 immune checkpoint blockades via the inhibition of STAT3 and PD-L1 signaling [20].