In summary, CK increased cytotoxicity without hurting normal cells, sub G1 population, cleaved PARP and decreased the expression of pro-caspase-3, VEGF, TGF-β, IL-6, IL-10, Cyclin D1, c-Myc and Bcl-xL in prostate cancer cells. This evidence concerns the gene CCND1 and Familial prostate cancer.