NFKB1 and rheumatoid arthritis: Furthermore, it was observed that overexpression of miR-410 significantly reduced the secretion of TNF-α, IL-1β, IL-6, and MMP-9 in human RA fibroblast-like synoviocytes (HFLS-RA), through the suppression of the activation of the NF-κB signaling pathway [177].