Notably, the antisense-mediated silencing of type 3 IP3R (IP3R3), but not type 1 IP3R, inhibited dexamethasone-induced apoptosis in the mouse S49 T-lymphoma cell line, suggesting that Ca2+ release via IP3R3 is required to trigger autophagy that inhibited apoptosis [29]. The gene discussed is ITPR3; the disease is lymphoma.