TARDBP and neurodegenerative disease: Several studies have shown that autophagy mediates the degradation of most of the protein aggregates associated with neurodegenerative diseases, including mutant huntingtin (mHTT), α-synuclein (α-syn), tau and TAR DNA-binding protein 43 (TDP43) and defects in the autophagy machinery causes the accumulation of the misfolded protein in the brain [124,125].