While WW domain-containing protein 2 (WWP2) has been identified as a HECT E3 ubiquitin ligase that mediates PTEN ubiquitylation [117,118] to induce apoptosis for tumor-cell survival, further investigation into the potential neuroprotective role that WWP2 may play regarding PTEN degradation is needed. The gene discussed is PTEN; the disease is neoplasm.