We found EC2319 significantly decreased the expression of the pro-fibrotic cytokine TGF-β and CCL2/MCP-1, a chemokine that is not only produced by activated macrophages but also plays a key role in the infiltration of these cells in anti-GBM GN [6,7,8,42,43] (Figure 4C,D). This evidence concerns the gene TGFB1 and ganglioneuroma.