Given the strongest display of ferroptosis-sensitive gene signature in IDH-mutant lower-grade glioma among all cancer types [55], we speculate that TP53 alteration is required to inhibit ferroptosis for gliomagenesis, especially for IDH1R132X gliomas, including oligodendroglioma, that are supersensitive to ferroptosis owing to the higher levels of D-2HG. This evidence concerns the gene IDH1 and central nervous system cancer.