IDH2 and cancer: To obtain a landscape of IDH1 and IDH2 mutations in human cancer, we analyzed samples from three independent pan-cancer datasets: TCGA PanCancer dataset (TCGA_PanCancer); MSK-Impact pan-cancer dataset (MSK_Impact); and a combined, non-redundant pan-cancer dataset (Non-Redundant), which comprised a total of 45,228 human samples with various cancer types (see Materials and Methods).