In contrast, whereas IDH1R132C is the major form in chondrosarcoma, cholangiocarcinoma, and acute myeloid leukemia [13], the co-occurrence of IDH1R132C and TP53 alteration was nearly eightfold greater in glioma compared with non-glioma (Figure S3), as was the co-occurrence of combined IDH1R132X (Figure 4B). Here, TP53 is linked to glioma.