Infusion with mesenchymal stem cells (MSC) restored PINK1/Parkin-mediated mitophagy and prevented endothelial cell apoptosis, thereby restoring endothelial cell function [92].Inducing mitophagy in diabetic platelets is a potential treatment for alleviating excessive oxidative stress associated with hyperglycemia. This evidence concerns the gene PRKN and Hyperglycemia.