PLA performed on hMSG biopsies obtained from a patient with sicca symptoms and no Sjögren’s syndrome (SICCA-NS) and with sicca symptoms and Sjögren’s syndrome (SICCA-SS) revealed AQP5-PIP complex formation, but there was no significant quantitative difference in the number of complexes (number of red spots) between the two groups (p = 0.55). The gene discussed is AQP5; the disease is Sjogren syndrome.