Cardiac ryanodine receptor (RyR2) mutations have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT) [2], ventricular fibrillation (VF) [3] and/or atrial fibrillation (AF) [4]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.