Vossen et al. [145] developed a punch biopsy transwell culture and revealed that, amongst a variety of anti-inflammatory drugs, including modern biologicals, TNF-α inhibitors and prednisolone showed the highest inhibitory effect on proinflammatory cytokines and AMPs in HS lesional skin which fits to the clinical experience regarding TNF-inhibitors. This evidence concerns the gene TNF and histiocytic sarcoma.