Normal plasma NEFA may have played an important part in insulin sensitivity, as supported by studies showing that treatment with acipimox, a lipolysis inhibitor, restored insulin’s suppression of endogenous glucose production without altering adipokines (IL-6 and TNFα) or adiponectin levels in subjects with a strong family history of type 2 diabetes [46]. This evidence concerns the gene TNF and type 2 diabetes mellitus.