KLF4 and cancer: Thus, cell type and context may determine the tumor suppressive and oncogenic role of KLF4. It is implicated in several roles in cancer; however, nearly all of the studies have suggested its tumor suppressive action, e.g., in gastric, colon and colorectal cancers, esophageal, lung and bladder cancer, T-cell leukemia and medulloblastoma [20,25,26,27,28,29,30,31].