TNF and early-onset autosomal dominant Alzheimer disease: In a Drosophila Alzheimer’s disease model, Wu et al. [84] showed that enterobacterial infection may exacerbate the progression of the disease by promoting immune hemocyte recruitment to the brain and neurodegeneration mediated by the TNF-JNK (tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase) signaling pathway.