However, Eph and IGF1 signaling pathways cross-talk to regulate bone and skeletal muscle cells function [211,212] and EphA2 and EphB4 exert oncogenic effects in different types of sarcomas, supporting the rationale for targeting Eph-dependent pathways in those tumors [208,213,214,215,216,217,218,219,220]. This evidence concerns the gene IGF1 and sarcoma.