For instance, recent data demonstrated that the mediator of EMT process cysteine-rich protein 61 (CYR61/CCN1), which correlates with osteosarcoma aggressiveness in preclinical model and in patient tumor samples, increased IGF1R and IGF1 expression in osteosarcoma cells, thereby modulating cell–cell interactions and motility [154]. Here, IGF1 is linked to osteosarcoma.