Whether IGF2BP3 might be a direct target of BET proteins and the molecular mechanism underlying this effect is not known at the moment but there is some evidence in Ewing sarcoma cells indicating that silencing of IGF2BP3 conferred resistance to JQ1, thereby supporting a connection between BET proteins and IGF2BP3 [244]. The gene discussed is IGF2BP3; the disease is Ewing sarcoma.