DNER and Ewing sarcoma: A rationale for co-targeting the IGF1R/Akt axis and BET proteins was provided in Ewing sarcoma where the expression of a constitutively active Akt significantly decreased sensitivity of Ewing sarcoma cells to the BET inhibitor NHWD870, suggesting a crucial role of the IGF1R/Akt cascade in resistance of Ewing sarcoma cells to BET inhibitors [239].