It is important to mention that, in addition to the IGF axis, several autocrine and paracrine signaling pathways might contribute to the malignant propensity of rhabdomyosarcoma histologic subtypes inlcuding the cMET, FGFR4 and PDGFR cascades, which all activate Akt signaling [173]. This evidence concerns the gene AKT1 and rhabdomyosarcoma.