Overall, the subset of Ewing sarcoma cells characterized by low levels of EWS-FLI1 have an increased metastatic potential, displaying increased expression of the YAP/TAZ/TEAD complex and upregulated expression of YAP/TAZ/TEAD target genes as compared to cells expressing high levels of EWS-FLI1. This evidence concerns the gene EWSR1 and Ewing sarcoma.