Indeed, one review summarized the potential use of TGR5 activators in the amelioration of NAFLD phenotypes via modulation of bile acid synthesis, lipid metabolism, and inflammation [91]; however, considering TGR5 is a key biliary receptor that mediates bile composition and bicarbonate secretion, it is important to look at impacts on the biliary tree. Here, GPBAR1 is linked to metabolic dysfunction-associated steatotic liver disease.