Downstream of S1PR2 activation is the induction of sphingosine kinase 2 (SPHK2) that can translocate to the nucleus to modulate gene synthesis, and in the same study above, the authors found that Sphk2−/− mice at 20 weeks of age spontaneously develop hepatic steatosis [95]. The gene discussed is SPHK2; the disease is fatty liver disease.