In the context of gliomas, we recently demonstrated that the infusion of m/lEVs derived from lipopolysaccharide/interferon-γ (LPS/IFN-γ)-treated microglia in glioma-bearing mice reduces tumor size, which is an effect due to the mRNA cargo capable to amplify the antitumor response of microglia [12]. The gene discussed is IFNG; the disease is central nervous system cancer.