The result was also confirmed on IL-4-stimulated microglial cells: BV2-derived sEVs were not able to modify the expression of pro-tumor genes (Arg-1, Cd163, Cd206, Fizz-1, and Ym1), with all of them upregulated by IL-4 treatment compared to the control cells (Figure S1E). The gene discussed is ARG1; the disease is neoplasm.