A genome-scale CRISPR-Cas9 screen has identified the inactivation of ARID2, BRG1, and BRD7—all of which are members of the PBAF form of the SWI/SNF complex—to be responsible for the sensitization of melanoma murine models to cytotoxic T-cells via an enhanced response to IFN-gamma [96]. The gene discussed is SMARCA4; the disease is melanoma.