Members of the bromodomain and extra-terminal motif (BET) protein family, such as bromodomain-containing proteins 2 (BRD2) and 4 (BRD4), which are able to recognize specific chromatin modifications and subsequently initiate downstream regulatory processes, are key controllers of cell cycle and survival gene expression and have been found to be overexpressed in melanoma cells. The gene discussed is BRD2; the disease is melanoma.