MGMT and metastatic melanoma: Combinations of decitabine plus temozolomide and decitabine/panobinostat plus temozolomide have been found to be safe and effective in treating metastatic melanoma; the synergistic effect might be explained by the restoration of aberrant methylation patterns linked with O-6-methylguanine-DNA methyltransferase (MGMT) hyperactivity [106,123].