ARHGEF3 and glioblastoma: Moreover, increased levels of immunoglobulin kappa J region (RBPJ) mRNA, which contributes to GBM malignancy and promotes proneural–mesenchymal transition via the IL-6/STA3 pathway [77], were evidenced in MES-like GSC#83 cells, suggesting that mesenchymal GSC#83 may be derived from a GSC with a proneural phenotype [15].