GPR31 and deep vein thrombosis: Moreover, the 12-HETE-GPR31 interaction has recently been described as a crucial process in the development of liver ischemia–reperfusion (IR) injury [130], and the 12(S)-HETE dependent GPR31 activation was shown to stimulate thrombin-PAR4 platelet activation and arterial thrombosis in human platelets via Gi activation, suggesting inhibition of this system as a beneficial strategy for the prevention of arterial thrombosis [131].