Overexpression of Pyk2 facilitates hepatocellular carcinoma (HCC) cell invasiveness by up-regulating phosphorylation of Src, ERK1/2, and MEK1/2 [54], and both Pyk2 and FAK interact with Src and p130Cas to regulate breast cancer motility and invasion [55]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.