PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Several studies have identified genetic variants associated with altered hepatic lipid metabolism through the impairment of VLDL secretion (APOB, TM6SF2 rs58542926 C>T) [50], increased storage of lipid droplets (PNPLA3 rs738409 C>G, MBOAT) [51,52], and regulation of de novo lipogenesis (GCKR rs780094 A>G, KLF6 rs3750861 G>A) [53] to be associated with NAFLD.