In particular, adiponectin, present in lower levels in NASH patients [38], has liver-protective functions by enhancing lipid clearance from plasma, stimulating beta-oxidation of FFAs, and also has anti-inflammatory effects by inhibiting the release of pro-inflammatory cytokines, such as TNFα and IL-6 [39]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.