In summary, STING agonists may be a compelling therapeutic strategy for gliomas because they: (1) can simulate a foreign body reaction, thus providing a “target”; (2) induce IFN, thereby providing potent T cell effector action; (3) induce chemokine production and thus T cell trafficking to the tumor; and they are (4) easy to synthesize. Here, STING1 is linked to central nervous system cancer.