MFN2 has been recognized as a direct substrate of calpain since in vitro calpain cleavage assays using recombinant proteins observed the cleavage of MFN2 by calpain in a dose- and time-dependent manner [124], although future work is needed to clarify whether this calpain-dependent cleavage of MFN2 contributes to cardiac diseases. Here, MFN2 is linked to heart disorder.