During myocardial ischemia/reperfusion, activation of mito-calpain results in the degradation of the NADH:ubiquinone oxidoreductase core subunit S7 (NDUFS7), a subunit essential for complex I activity, which could be prevented by the calpain inhibitor MDL-28170 [10]. This evidence concerns the gene NDUFS7 and myocardial ischemia.