The deregulation of OGN has also been observed in colorectal adenomas, the major precursor lesion of colorectal cancer [41], the overexpression of this gene in mouse hepatocellular carcinoma caused a decrease in invasion and metastasis capacity [41], while its overexpression in CCs has been related to longer survival and the restriction of tumor progression [42]. Here, OGN is linked to hepatocellular carcinoma.