Interestingly, the SARS-CoV2 functional interactome described by Hoffmann and collaborators identified MIB1 (Mindbomb 1), an E3 ubiquitin-protein ligase, as a mediator of TBK1 activation and, consequently, having a role for integrating signals in response to viral infection through RIG-like receptors and IRF3 [10]. The gene discussed is UBE2E3; the disease is viral infectious disease.