RIGI and infection: All of these functions have been related to the functional effect of ORF9b, which inhibits RIG-1-MAVS antiviral signaling during the host’s cell infection, and manipulates the host’s cell mitochondria and mitochondrial function to help SARS-CoV2 escape the host’s innate immunity, as shown with previous strains of coronaviruses (e.g., SARS-CoV1) [10,70].