YIF1A interacts with a complex belonging to the ER, vesicle-associated membrane protein-associated protein B (VAPB), and the mitochondrial membrane protein, protein tyrosine phosphatase interacting protein-51 (PTPIP51), involved in signaling between the ER and mitochondria, an interaction whose dysfunction has been related to neurodegenerative diseases [62]. The gene discussed is YIF1A; the disease is neurodegenerative disease.