Many pro-inflammatory factors involved in cytokine storms during COVID-19 are antagonized by JAK inhibitors, such as IL-6, a multifunctional cytokine exerting its action through the IL-6 receptor (IL-6R) and the downstream activation of the JAK/STAT and MAPK (mitogen-activated protein kinase) pathways [129]. The gene discussed is IL6; the disease is COVID-19.