In autosomal dominant forms of sarcoidosis and based on the SARS-CoV2 GHI, the results of our study confirmed a significant accumulation of pathogenic variants in genes regulating the RIG-I (Retinoic acid-Inducible Gene I)–MAVS (Mitochondrial Antiviral Signaling Protein)-dependent type I IFN (Interferon) signaling pathway (Figure 4a). Here, RIGI is linked to sarcoidosis.