Nevertheless, gene expression analysis of oncogenes in human urothelial cells confronted with both schistosome species revealed that only S. mansoni eggs induced a significant dysregulation of the CRC signaling pathways, including the upregulation of TNF, RUNX1, the proto-oncogenes c-Myc and c-Jun, NF-κB1, Scr, and Bcl-2 [160]. This evidence concerns the gene MYC and colorectal carcinoma.