The mechanisms involved in oncogene activation, tumor suppressor gene inactivation, chromosomal rearrangement in combination with immune- and inflammatory responses such as the induction of auto-aggressive CXCR6+ CD8+ T-cells and PD1+ CD8+ T-cells, telomere shortening, DNA damage, oxidative stress, and autophagy are crucial for HCC development [65,66,67,68,69]. Here, CD8A is linked to hepatocellular carcinoma.