TG and goiter: Notably, no apparent goiter was found in tshba mutant zebrafish (Supplementary Figure S2), while typical goiters of a large red protrusive mass were observed under the jaw and anterior to the heart in tg and slc16a2 mutant zebrafish at 3 mpf (Figure 9A–E), and the mass in tg mutant zebrafish was larger than that in slc16a2 mutant zebrafish.