This inference is supported by previous studies, showing that unilateral ocular hypertension and axotomy induce contralateral microglial cell activation (e.g., the advent of microglial cells with activated form, MHC-II upregulation, and increase in Iba-1-labeled microglial cell number) [41] and retinal neuronal degeneration in the contralateral eye [42]. This evidence concerns the gene AIF1 and ocular hypertension.