Moreover, CXCL8 was revealed to play a significant role by promoting tumor formation, progression, and invasion via activating phosphoinositide 3-kinase (PI3K) signaling, which subsequently phosphorylates protein kinase B (PKB) also known as (AKT) and MAPK in breast cancer and CRC [29,30]. Here, AKT1 is linked to colorectal carcinoma.