CXCL8 and neoplasm: Recent reports demonstrated that solid colon tumors express different kinds of chemokines, including a member of the CXC chemokine family, C-X-C motif chemokine ligand 8 (CXCL8), also known as interleukin (IL)-8 [7,25], In addition, CXCL8 functions as an inflammatory cytokine secreted by immune cells, such as macrophages within the tumor microenvironment (TME) [26,27].