Additionally, high expression levels of c-MYC were demonstrated to regulate antitumor immune responses, by mediating programmed death ligand 1 (PD-L1) and cluster of differentiation 47 (CD47) [18], as well as promoting CRC tumor recurrence after 5-fluorouracil (5-FU)-based adjuvant chemotherapy [19]. This evidence concerns the gene MYC and neoplasm.