CXCL8 and colorectal carcinoma: In the current study, we used computation studies through a bioinformatics analysis to identify and validate expressions of the c-MYC/CXCL8/TIMP1 signaling pathway in CRC, and used in silico molecular docking to evaluate potential interactions of the RV59 with MYC/CXCL8/TIMP1 signaling.