PTGS2 and gastric ulcer: The molecular events in granulation tissue that contribute to the mechanisms of gastric ulcer healing include the activation of genes encoding bFGF, FGF-R1,2,4, VEGF, and flk-1/KDR; Ang 1 and Ang 2; Tie 2 receptor; COX-2; SRF; NGF; SDF-1; and BMD-EPC via the activation of PI3K/Akt pathway.