These co-occurring mutations are not restricted to MPN, but occur also in other myeloid malignancies including acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and MDS/MPN overlap diseases, as well as in healthy individuals in the context of age-related clonal hematopoiesis (ARCH/CHIP) [44,47]. Here, STUB1 is linked to acute myeloid leukemia.