BRAF and Miyoshi myopathy: Overall, an average of 1.6 mutations per Mb were observed in MM but no universal driver mutations were identified, with the most frequently mutated genes reported being KRAS and NRAS (in ~20% of patients each), followed by FAM46C and DIS3 (~11% each), TP53 (8%) and BRAF (6%) [8,82,83,84,85,87,88].