Beyond these well-defined myeloma genes, recent NGS-based studies have identified several other mutated genes, such as linker histones (HIST1H1B, HIST1H1D, HIST1H1E, and HIST1H2BK) [87], FUBP1 (MYC transcription regulator) and MAX (MYC DNA binding partner) [87], and non-coding mutations in the cis-regulatory elements (e.g., HOXB3, PAX5 and TPRG1) [85]. The gene discussed is MYC; the disease is plasma cell myeloma.