Although two-thirds of MM patients carry translocations in either IgH or MYC, a recent MM WGS study showed that there were more than 2000 SVs present in MM with IgH and MYC translations only accounted for 6.5% of all SVs [87], suggesting the importance of SVs as major drivers of MM development and progression. This evidence concerns the gene MYC and Miyoshi myopathy.