BCL2 and adenocarcinoma: In addition, it was observed in a previous study that a concentration of 12 μM of commercial H2O2, or produced by the enzymatic reaction, BSAO/SPM, caused an increment in mRNA levels for the BAX proapoptotic gene in adenocarcinomas multidrug-resistant LoVo DX cells, while the pro-survival Bcl-2 gene did not expose any difference after the treatment with hydrogen peroxide [67].