In addition, the human leukemia OCI-AML3 cell line, which expresses a mutated form of NPM1 sequestered in the cytoplasm (NPMc+) and frequently found in Acute Myeloid Leukemia (AML) [53], harbors reduced 2′Ome at positions 28S-Cm1327, 28S-Cm3866, 28S-Um3904, and 28S-Gm4198, while respective SNORD levels remains unchanged. Here, NPM1 is linked to acute myeloid leukemia.