However, the observed increase in the rRNA 2′Ome level in some DLCBL and AML1-ETO-driven AML patients, and the correlation between SNORD expression and rRNA 2′Ome levels suggests that the variation of rRNA 2′Ome, at least at some sites, is cancer-specific or even tumor-specific [32,52,70]. Here, RUNX1 is linked to acute myeloid leukemia.