Interestingly, AML1-ETO positive patients’ primary AML blasts overexpress specific SNORDs, including SNORD14D/14E/20/32A/34/35A/43/53/104 and displays increased 2′Ome at positions 18S-Um1805, 28S-Um4197, 28S-Cm3848, 18S-Cm1703, and 18S-Gm1328. This evidence concerns the gene RUNX1 and acute myeloid leukemia.