TP53 and colorectal cancer: Using an isogenic colorectal cancer cell line HCT116, Sharma and colleagues reported using RiboMeth-seq, and that, among the 22 partially methylated sites, 13 sites showed a decrease in rRNA 2′Ome level in p53 −/− cell line compared to p53 +/+ one, demonstrating that some 2′Ome sites are particularly sensitive to the absence of functional p53 [49].