ZC3HC1 and neoplasm: Of further note, cellular amounts of ZC3HC1 appeared somewhat reduced in HeLa and other human tumour cell lines, like HCT116, in which TPR had been knocked down by RNAi too (Figure 5(B1,B2)), and in U-2 OS cells, such reduction upon TPR RNAi was particularly striking (Figure 5(B2)).