Of interest, in our work, we did not find significant correlations between CSF MMP-10 and p-tau/t-tau, while MMP-10 protein levels were found to be negatively correlated with CSF Aβ42 levels in AD-MCI patients (ρ = −0.37, p < 0.05), thus supporting a possible interaction between this specific metalloproteinase and amyloid pathology in AD patients. The gene discussed is MAPT; the disease is Alzheimer disease.