MAPT and Alzheimer disease: In AD, amyloid-β (Aβ) pathology has long been considered as the central event in the pathophysiology of the disease, followed by the intraneuronal aggregation of misfolded and phosphorylated tau protein in form of neuritic plaques, neurofibrillary tangles, and neuropil threads, leading to neurodegeneration and ultimately neuronal death [2].