ARHGAP24 and glaucoma: Of the three genes found in cluster C, only ARHGAP24 (cluster C, FC = −2.04), which encodes a protein that participates in cell-ECM adhesion complexes in cultured HTM cells [88], has any relevance to TM function or glaucoma as it has also been identified in cultured ONH astrocytes as being phosphorylated in response to increases in hydrostatic pressure [89].