CACNB3 and anterior segment dysgenesis: Other genes of interest are PAX6, LMX1B and DDIT3. PAX6 (FC = 2.78) is significantly upregulated in CAβ3 vs. WTβ3 cells like the genes in clusters L and M. It has been shown to play a role in anterior segment dysgenesis (ASD) [53] and is linked to glaucoma (Table 2).