Among the genes upregulated and associated with glaucoma were several components of the ECM (POSTN, COL8A2, SEMA6A) as well as ANGPT1 and BMP4. We also found a decrease in expression of several genes associated with the ECM especially MMP1 and TIMP3. These genes all have one thing in common and that is their expression would affect the remodeling of ECM. The gene discussed is TIMP3; the disease is glaucoma.