Finally, two other genes of interest that appeared on the cytokine heat map were TNFAIP3 and PENK. TNFAIP3 (Figure 7, cluster K) was downregulated only in CAβ3 cells (FC = −1.92), and changes in expression of this gene have been associated with glaucoma (Table 2). The gene discussed is PENK; the disease is glaucoma.