KRAS and lung adenocarcinoma: This is possible when the SMARCA4 in a KRAS-dependent lung adenocarcinoma is a missense mutation, identified through an intact BRG1 expression or the loss of BRG1 expression caused by a nonsense, frameshift, or splice site mutation in the SMARCA4 gene in a KRAS-independent lung adenocarcinoma [7,43].