Since fibrosis is an important mediator of HCC progression [40], HCC samples were grouped based on their relative fibrosis levels in terms of the Metavir scoring system [41] before undergoing GSEA with the “TF.Target.ENCODE” database and subsequent scatter plot construction, to delineate the modalities of the regulatory modules in AILD-mediated HCC development through fibrotic progression. The gene discussed is TF; the disease is hepatocellular carcinoma.