The analysis predicted 2 hub genes (DCAF11 and PKM2) in terms of progression free survival (Figure 8A), 2 hub genes (PKM2 and BCAT1) in terms of disease specific survival (Figure 8B) and 4 hub genes (DCAF11, PKM2, DGAT2 and BCAT1) in terms of overall survival Figure 8C) to show significant (p < 0.05) differences between the survival kinetics of HCC patients exhibiting low and high expression levels of these genes. This evidence concerns the gene PKM and hepatocellular carcinoma.