In general, groups with different etiologies with stronger negative correlation between AILD and HCC gene expression signatures exhibited less positive HCC:AILD NES ratio for three of these modules, namely ENCODE:BCL11A, ENCODE:MEF2C, ENCODE:IKZF1 (Figure 3E), suggesting a possibly greater importance of these modules in regulating the appearance of HCC signatures in AILD-affected liver tissues. This evidence concerns the gene IKZF1 and hepatocellular carcinoma.