Specifically, we observed the upregulation of major pro-angiogenic factors, i.e., VEGF, VEGFR-2, Ang-2, and HIF-1α [11,26] in skeletal muscles of HF patients post-training, as well as several correlations between the post-exercise training changes in skeletal muscle expression of the angiogenic factors examined in these patients. The gene discussed is ANGPT2; the disease is hydrops fetalis.