B1R antagonism or deletion plays a protective role in inflammation, organ damage, and lethal thrombosis in septic shock in diabetes [53]; lipopolysaccharide (LPS) mediated acute renal inflammation [54]; renal ischemia-reperfusion injury [55]; and in cardiovascular [56] and retinal [57,58,59,60] inflammatory diseases. The gene discussed is BDKRB1; the disease is diabetes mellitus.