In studies of mice bearing sarcoma 180 cells, it was suggested that BK promotes angiogenesis in the early phase of tumor development by increasing vascular permeability via B2R, expressed in the endothelial cells and not via B1R, and in the late phase by stimulating the upregulation of VEGF via B2R in the stromal fibroblasts [85,86,87]. This evidence concerns the gene VEGFA and neoplasm.