CTNNB1 and Other metabolic disease: In one study, three major subtypes of HCC were identified: (1) mitogenic and stem cell-like tumors with chromosomal instability; (2) CTNNB1-mutated tumors (CTNNB1 codes for β-catenin) displaying immune suppression; and (3) metabolic disease-associated tumors, which included an immunogenic subgroup characterized by macrophage infiltration and favorable prognosis [67].