Importantly, chronic activation of NF-κB has been observed in numerous diseases associated with ageing [3], including muscular atrophy [53], atherosclerosis [54], osteoporosis [55], heart diseases [56], type 1 and type 2 diabetes [57,58], osteoarthritis [59], and neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease [60,61,62,63]. Here, NFKB1 is linked to osteoporosis.