Skin changes associated with premature ageing were also reversed in the p16INK4a mouse model of acute radiation dermatitis as a consequence of the attenuation of the expression of NF-κB-dependent genes [75]; in IKKβ mice that suffer muscle wasting (which represent a model of sarcopenia, i.e., muscle loss due to ageing), NF-κB blockade reversed muscle ageing manifestations [53]; similarly, a mouse model of DMD (dystrophin-deficient mice) and progeria, the deletion of one allele of Rela or the lack of Ikkβ, reversed the ageing features and muscle pathology [76] (Table 1). Here, IKBKB is linked to progeroid syndrome.