NFKB1 and cancer: Therefore, its preponderant role in inflammation, together with the previous findings showing that pro-ageing stimuli activate NF-κB signaling while those with an anti-ageing effect inhibit it and, more importantly, that the inhibition of NF-κB activity can delay and even reverse ageing manifestations in human and mouse models of ageing, has made NF-κB a key protein complex that acts as a driver for ageing and to be considered as a potential therapeutic target to prevent premature ageing and age-related diseases, including cancer [3,6,7].