KEAP1 and hepatocellular carcinoma: Under stress conditions, binding of the substrate adaptor p62 to Kelch-like ECH-associated protein 1 (Keap1) activates NRF2-binding AREs, leading to the expression of NRF2 target genes such as NQO1, HO-1, and FTH1 and resulting ultimately in HCC proliferation [76].