GAPDH and hepatocellular carcinoma: Takashi Hamaguchi et al. also reported that HCC tissues exhibit markedly increased levels of eight glycolytic genes (GPI, ALDOA, TPI1, GAPD, PGK, PGAM, ENO1, and PKM), which can be transcriptionally activated by HIF-1α, and that these increases are related to poor survival [72].