Linalool activates Nrf2, and was shown to reverse the decreased expression of synaptic plasticity-related proteins, including calcium-calmodulin-dependent protein kinase II (CaMKII), p-CaMKII, brain derived neurotrophic factor (BDNF), and tropomyosin-related kinase B (TrkB) in the hippocampus in an oxidative stress AD mouse model [68]. This evidence concerns the gene NTRK2 and Alzheimer disease.