KEAP1 and neoplasm: Regarding other lung cancer sub-types, Keap1 mutations have been found in an LCC tumor in mice [15], in SCLC (NCI-H1184, a human cell line) [16] and in some pulmonary large-cell neuroendocrine carcinoma (LCNECs) [17], although at a lower frequency than in LUSC or LUAD.