Another family of NRF2 effectors are the aldo-keto reductases (AKRs, AKR1B, AKR1C1/2 and AKR1C3) which are upregulated in many LUSC and some LUAD tumor biopsies with somatic mutations in the NFE2L2 gene [120]. The gene discussed is AKR1C1; the disease is neoplasm.