In recent years, targeted therapy (inhibitors of EGFR, ALK or ROS1 for NSCLC and inhibitors of PARP or DLL3 for SCLC) and immunotherapy (pembrolizumab, nivolumab, durvalumab, etc.)have been incorporated as therapeutic strategies for NSCLC and SCLC [185,186,187]. Here, DLL3 is linked to small cell lung carcinoma.