For example, alpha-synuclein in Parkinson’s disease; amyloid-beta (Aβ) and hyperphosphorylated tau (p-tau) in Alzheimer’s disease; mutant huntingtin proteins in Huntington’s disease, and mutant superoxide dismutase 1 (SOD1) and TAR DNA binding protein 43 (TDP-43) in amyotrophic lateral sclerosis. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.