LIPG and myocardial infarction: To further explore the possible causal relevance of HDL-C in the risk of myocardial infarction, Voight et al. performed two Mendelian randomization analyses, using both a single-nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser), and a genetic score consisting of 14 common SNPs that exclusively associate with increased HDL-C [71].