In the Copenhagen City Heart Study [76], individuals carrying four vs. no HDL-C-increasing alleles of two common genetic variants in CETP associated with reduced CETP activity showed an increase in HDL-C up to 14%, and concomitant decreases in TGs and LDL-C levels, with corresponding risk reductions in IHD (HR 0.74 (95% CI: 0.65 to 0.85)) and myocardial infarction (0.65 (95% CI: 0.54 to 0.79)). The gene discussed is CETP; the disease is myocardial ischemia.