EMD and Emery-Dreifuss muscular dystrophy: Emerin, whose loss of function causes Emery-Dreifuss muscular dystrophy, is a LAP2-emerin-MAN1 (LEM) domain protein [165] that plays a key role in the organisation of the nuclear lamina and its association with chromatin, as well as in transcriptional regulation, mitosis, and nuclear assembly (reviewed in [166]).